COGNITIVE IMPAIRMENT IN LONG-COVID SYNDROME (BRAIN FOG): NEUROINFLAMMATORY MARKERS AND LONG-TERM PROGNOSES
Keywords:
Long-COVID syndrome, Brain Fog, NeuroinflammationAbstract
Background: Long-COVID syndrome, or the post-acute sequelae of SARS-CoV-2 infection, has emerged as a significant public health challenge, with "brain fog" being one of its most debilitating neurological manifestations. This cognitive dysfunction encompasses deficits in attention, executive function, and memory, severely impacting the quality of life. This article explores the underlying mechanisms of cognitive impairment in Long-COVID patients, focusing on the pivotal role of neuroinflammatory markers and evaluating long-term clinical prognoses.
References
1. Al-Aly, Z., Bowe, B., & Xie, Y. (2022). Long-term neurologic outcomes of COVID-19. Nature Medicine, 28(10), 2205-2214.
2. Ceban, F., et al. (2022). Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain, Behavior, and Immunity, 101, 93-135.
3. Davis, H. E., et al. (2023). Long COVID: Mechanisms, risk factors and management. Nature Reviews Microbiology, 21(3), 133-146.
4. Douaud, G., et al. (2022). SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature, 604(7907), 697-707.
5. Fernández-Castañeda, V., et al. (2022). Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell, 185(14), 2452-2468.
6. Kappelmann, N., et al. (2024). Neuroinflammatory markers in Long-COVID: A longitudinal perspective on IL-6 and TNF-alpha. Journal of Neuroinflammation, 21(1), 45-58.
7. Mavrikaki, M., et al. (2022). Severe COVID-19 is associated with molecular signatures of inflammation and aging in the central nervous system. Nature Aging, 2(12), 1130-1144.
8. Monje, M., & Iwasaki, A. (2022). The neurobiology of Long COVID. Neuron, 110(21), 3484-3496.
9. Spudich, S., & Nath, A. (2022). Nervous system consequences of COVID-19. Science, 375(6578), 267-269.
10. Zheng, L., et al. (2025). The role of microglial activation in persistent "Brain Fog": New therapeutic targets in the post-pandemic era. Lancet Neurology, 24(2), 112-125.
