ETIOLOGY AND PATHOMORPHOLOGY OF UTERINE FIBROIDS

Abstract

Uterine fibroids (leiomyomas) are the most common benign tumors of the female reproductive system and arise from the smooth muscle cells of the uterine myometrium. Their development is influenced by multiple factors including hormonal imbalance, genetic predisposition, growth factors, and environmental influences. Pathomorphologically, fibroids are characterized by well-circumscribed nodules composed of smooth muscle cells arranged in whorled bundles with varying degrees of fibrous connective tissue. Understanding the etiology and morphological characteristics of uterine fibroids is essential for improving diagnosis, prevention, and therapeutic strategies in gynecological practice.