ETIOLOGY, CLINICAL STAGES, AND TREATMENT MODALITIES OF ACNE VULGARIS
Keywords:
acne vulgaris, etiology, pathogenesis, comedone, inflammationAbstract
Although it is often interpreted as a temporary adolescent skin problem, modern dermatology considers acne a multifactorial disease involving follicular hyperkeratinization, increased sebum production, Cutibacterium acnes-associated microbial activity, immune inflammation, hormonal influence, genetic predisposition, environmental exposure, and behavioral skin-care factors. The study uses a descriptive analytical design based on clinical guidelines, dermatological textbooks, national protocols, and scientific literature. The results show that successful acne management depends on correct severity classification, early recognition of scarring risk, rational use of topical and systemic therapies, avoidance of antibiotic monotherapy, patient education, and long-term maintenance care. The article is intended for educational and scientific purposes and does not replace individual medical consultation
References
1. Narzikulov R. M., Klebleyeva G. D. Dermatovenerology: Training Manual. Samarkand: Samarkand State Medical University, 2023.
2. Malikova N. N., Arifov S. S., Khodjaeva M. B. Acne Therapy: Literature Review. Dermatology and Aesthetic Medicine. Tashkent, 2025.
3. Karimqulovich R. M. Improvement of Treatment of Acne Vulgaris Using a New Combined Treatment Method. Scientific Article. Uzbekistan, 2024.
4. Eshboyev E. X., Tashkenbayeva U. A. Dermatovenerology: Educational Literature. Tashkent: Uzbekistan Medical Education Publications.
5. Technology of Special Dosage Forms: Educational Manual. Section on Dermatological and Cosmetic Dosage Forms. Tashkent: Uzbekistan, 2018.
6. Arifov S. S. Dermatology and Venereology: Selected Lectures for Medical Students. Tashkent: Medical Publishing House.
7. Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology. Educational materials on inflammatory dermatoses and acne care. Tashkent: Uzbekistan.
8. Reynolds R. V., Yeung H., Cheng C. E., et al. Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology. 2024.
9. American Academy of Dermatology. Acne clinical guideline: guideline highlights and treatment recommendations. United States, 2024.
10. National Institute for Health and Care Excellence. Acne vulgaris: management. NICE Guideline NG198. London: NICE, 2021, updated 2026.
11. Sutaria A. H., Masood S., Saleh H. M., Schlessinger J. Acne Vulgaris. Treasure Island: StatPearls Publishing, latest update 2023.
12. Ministry of Health of the Republic of Uzbekistan. National Clinical Protocol for Acne Nosology. Tashkent: Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, 2025.
