ASSESSING THE IMPACT OF ANTIHYPERTENSIVE DRUGS ON THE CLINICAL PICTURE AND COURSE OF HYPERTENSION IN ELDERLY PATIENTS WHO HAVE HAD COVID-19

Umarov Zohidjon Asqarali ugli

Authors

Umarov Zohidjon Asqarali ugli Assistant Department of Internal Medicine, Central Asian Medical University. Fergana, Uzbekistan.

Keywords:

(SARS) -CoV-2 new coronavirus infection, antihypertensive drugs, ARBs, BB, CCB, acute respiratory distress syndrome, RAAS.

Abstract

The severe acute respiratory syndrome (SARS)-CoV-2 novel coronavirus (CoV) outbreak began in late 2019 in Wuhan, China, and has spread to more than 200 countries. We receive in this information the databases and archives of Fergana branch of the republican specialized scientific-practical medical center of cardiology. In a retrospective study, we identified 80 adult patients who had COVID-19 with laboratory confirmed tests. Multivariate logistic regression was performed in patients with comorbid hypertension to examine the potential association between clinical outcomes, disease severity, and clinical characteristics using ACEIs, ARBs, calcium channel blockers (CCBs), beta blockers (BBs), and thiazides. Clinical outcomes, shortness of breath, and fatigue were significantly reduced in patients, especially adult patients over 65 years of age, who were taking an ARB before hospitalization compared with patients who were not taking medication. Reduced disease severity in older patients with COVID-19 was associated with users of CCBs and ACEIs. Clinical parameters including CRP, lymphocyte count, D dimer, procalcitonin, and hemoglobin were significantly improved in older ARB users.

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