ASSESSMENT OF PHARMACOLOGICAL PROPERTIES OF A NEW PHYTOCOMPOSITION
Abstract
In an experiment, the antiexudative, analgesic and antipyritic activity of a phytocomposition consisting of extracts of medicinal plants Herba alhagi, Folium Uvae ursi, Fructus Rosae, Glycyrrhiza glabra and Flores chamomillae was studied on adult male rats and mice. It has been established that the studied phytocomposition has distinct pharmacological properties, so it suppresses exudation processes, reduces the threshold of pain sensitivity and elevated body temperature. In terms of its pharmacological activity, the phytocomposition is superior to canephron and not noticeably inferior to diclofenac sodium. It is believed that the new phytocomposition may be a potential anti-inflammatory medicine for the pharmacotherapy of diseases in the pathogenesis of which inflammation plays a significant role.
References
Chichasova N.V., Lila A.M. Etoricoxib - 15 years in Russia: main results of treatment of rheumatic diseases. //Attending doctor. - 2024. - No. 1 (27). - P. 42-48. https://doi.org/10.51793/OS.2024.27.1.006
Esedov E. M., Medzhidova R. A., Abasova A. S. Drug-induced liver damage in the clinic of internal diseases // Science and innovations - modern concepts. – 2023. – P. 106-114.
Konyshko N.A., Morozova T.E., Tsurko V.V., Konyshko G.S. Hyperuricemia, gout and pathology of the digestive system: common links in pathogenesis. //Experimental and clinical gastroenterology. - 2023. -№11. - P.130-137. https://doi.org/10.31146/1682-8658-ecg-219-11-130-137
Sibirkina M.V., Marufkhanov Kh.M. State of the gastrointestinal tract and microbiocenosis in rheumatological patients while taking NSAIDs // Bulletin of the Tashkent Medical Academy. -2024. -No. 3. -P.167-172.
Farah RI, Khatib AE, Abu Ziyad HJ, Jiad DK, Al Qusous LR, Ababneh AJ, Ajarmeh S. Pattern of use and awareness of side-effects of non-steroidal anti-inflammatory drugs in the Jordanian population. // Annals of Medicine 2023.-V. 55, N. 2.-R. 2242248 doi: 10.1080/07853890.2023.2242248.
Haley RM, von Recum HA. Localized and targeted delivery of NSAIDs for treatment of inflammation: //A review. Exp. Biol. Med. (Maywood). - 2019. - Apr;244(6). -R.433-444. doi: 10.1177/1535370218787770.
Dydykina I.S., Kovalenko P.S., Menshikova L.V. Efficacy and safety of NSAID therapy: focus on nimesulide // Effective pharmacotherapy. - 2020. - T. 16, No. 6. - P. 44–49.
Narovlyansky A.N., Poloskov V.V., Ivanova A.M. and co-author. Interferon-regulating activity of an antiviral drug for influenza and its effect on the expression of innate immune genes and the formation of reactive oxygen species in patients with follicular lymphoma. // Questions of virology. -2020. –Vol. 65, No. 5. -P.284-293.
Nasonov E.L., Rituximab In the book: Genetically engineered biological drugs in the treatment of rheumatoid arthritis. Edited by E.L. Nasonov, M.: IMA-PRESS. -2013. -P.200-221.
Rakhmonov K.S., Khaidar-Zade L.N., Kuzieva M.K. Prospects for the industrial cultivation of medicinal plants in Uzbekistan and their use in the production of flour products//Universum: technical sciences: electronic scientific journal. -2024. -No. 2(119). -P.45-52. URL: https://7universum.com/tech/archive/item/16903.
Khakimov Z. Z., Rakhmanov A. X., Khadzhieva U. A., Tursunova L. I. Antiexudative Activity of a New Phytocomposition Consisting from the Flora of Central Asia//American Journal of Medicine and Medical Sciences. - 2023.-№13(2). -R. 39-42. DOI: 10.5923/j.ajmms.20231302.01.
Khakimov Z.Z., Babazhanov A.U., Rakhmanov A. Kh. et all. L. Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation. // Advance in Biological Research. -2023. -N 4(1). -P.25-30. DOI: 10.26855/abr.2023.06.005.
Khakimov Z.Z., Babazhanov A.U., Rakhmanov A.Kh. et all. Multicomponent Photocomposition as a Source for Development of New Anti-Inflammatory Medicines. // Texas Journal of Medical Science (TJMS) ISSN NO: 2770-2936 https: //zienjournals.com. Date of Publication:06-05-2023/- Vol. 20.-R.29-32.
European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes: Council of Europe. Strasbourg. - 1986.-No. 51.-R.29–34. [Google Scholar]
Nesterova Yu. V., Povetieva, T. N., Suslov N. I. et all. Anti-Infl ammatory Activity of Diterpene Alkaloids from Aconitum baikalense. // Bulletin of Experimental Biology and Medicine. - 2014.-Vol. 156, No. 5.-R.665-668.
Mironov A.N. Guidelines for conducting preclinical studies of medicinal products. M.: Grif i K., 2012. 941 p.
Vasilyuk A.A. Study of the antipyretic activity of new piperidine derivatives in a model of yeast-induced fever. //Fundamental science in modern medicine. BSMU, Minsk. -2021. -P.365-369.
Necas, J. Carrageenan: a review / J. Necas, L. Bartosikova.// Veterinarni Med. 2013.- V. 58, N 4.- P. 187–205.
Usova, A.V., Popkova Yu.A., Filippova E.V. Experimental study and assessment of the benefits of using tranquilizers and neuroleptics in combination with an antioxidant / A. V. Usova, Yu. A. Popkova, E. V. Filippova. // Current issues of modern medical science and healthcare: materials of the VII International scientific-practical conference of young scientists and students, Ekaterinburg, May 17-18, 2022 - Ekaterinburg: USMU, 2022. - pp. 2894-2899.
Syrova A, Lukyanova L, Kozub S. et all. Investigation of the Peripheral Analgesic Activity of Oxicams and Their Combinations with Caffeine. //Turk J Pharm Sci.- 2020.- Aug;17(4). - R.408-411. doi: 10.4274/tjps. galenos. 2019. 92063.
Ivanova E.A., Voronina T.A. The effect of the main metabolite of afobazole M-11 on acute exudative inflammation and visceral pain in mice. //Pharmacokinetics and Pharmacodynamics. -2016. -No. 2. -P.46-48.
Dairov A.K., Romanova M.A., Seidakhmetova R.B. and co-author. Biological screening of natural compounds and their derivatives using PASS prediction. // Bulletin of Karaganda University. Series “Biology. Medicine. Geography". -2015. - No. 4(80). -P.10-16.
Bibik E.Yu.1, Kurbanov L.I.1, Grygoryan S.A. et all. The analgesic activity of new sulfur-containing di- and tetrahydropyridine derivatives in the hot plate test. // Journal of Siberian Medical Sciences. -2021. -No. 3. -R. 45–55.
Khakimov Z.Z., Rakhmanov A.Kh., Mavlanov Sh.R. Anti-inflammatory activity of a mixture of medicinal plants. LLC "TIBBIYOT NASHRIOTI MATBAA UYI", Tashkent. -2022. - 228 p.
Pathophysiology: textbook: in 2 volumes / ed. V. V. Novitsky, O. I. Urazova. — 5th ed., revised. and additional - M.: GEOTAR-Media, 2018. - T. 2. - 592 p.
Dangarembizi R., Erlwanger K.H., Rummel C. et all. Show more Brewer's yeast is a potent inducer of fever, sickness behavior and inflammation within the brain. // Brain, Behavior, and Immunity. February 2018, V. 68.-P. 211-223
Mehnoor Farheen, Mehtab Malik, Sheema Tarannum, Aisha Zareen Nawaz. Invivo Antipyretic Effects of Herbal Extracts on Brewer’s Yeast Induced Pyrexia in Rats. // IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN:2278-3008, p-ISSN:2319-7676. Volume 16, Issue 5 Ser. II (Sep. – Oct. 2021), P.60-71. www.Iosrjournals.Org.
Nishanbaev Kh.M., Bobakulov N.Yu., Beshko I.D. and co-author. Flavonoids of the aerial part of Alhagi Сanescens flora of Uzbekistan. //Chemistry of plant raw materials. -2017. -No. 1. -P.77-83.
A. V. Stepanova, S. S. Kuzmina, V. V. Anshakova, M. I. Solovyova Antioxidant properties of leaves of Arctostaphylos uva-ursi L. and Vacciniumvitis-idaea L. as part of a biocomplex based on lichens. // Bulletin of NEFU. - 2017. -No. 5. - P.26-36.
Zverev Ya.F. Flavanoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activity//Reviews on clinical pharmacology and drug therapy. -2017. -T.15, No. 4. -P.5-13.
Khakimov Z.Z., Rakhmanov A.Kh., Babazhanov A.U. Preclinical toxicological studies of the phytocomposition – dorusima. // Journal of Medicine and Innovation. -2023. -No. 3(11). -P.183-192.
