STUDYING THE CLINICAL EFFECTIVENESS OF THE DIETARY SUPPLEMENT “SUSTAVIN” IN ADDITION TO STANDARD THERAPY FOR OSTEOARTHRITIS OF THE KNEE JOINTS

Buranova S.N.

Authors

Buranova S.N. Tashkent Medical Academy

Keywords:

Osteoarthritis, cartilage oligomeric matrix protein, knee joint, Sustavin

Abstract

The purpose of this study was to study the clinical effectiveness of Sustavin in osteoarthritis (OA) of the knee joints (KJ). Material and methods: The study involved 50 patients diagnosed with stage 1-2 knee OA and 10 healthy volunteers. Patients in the control group (n=24) received a standard treatment regimen, while patients in the main group (n=26) received Sustavin along with standard therapy. Results: in patients of the main group, in addition to clinical improvement and reduction in the intensity of pain in the joint, the levels of COMP, CRP, and ESR in the blood serum decreased compared to patients in the control group, which indicated a beneficial effect of Sustavin on the functionality of the joint.

References

Buranova S.N., Akhmedov Kh.S., Razakova F.S. Cartilage oligomeric matrix protein (COMP) in early diagnosis of osteoarthritis. // The Chinese Journal of Occupational Diseases of Labor and Health.2021, №7(39) -P. 93-100.

Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115-2126.

Felson DT, Hodgson R. Identifying and Treating Pre-Clinical and Early Osteoarthritis. Rheum Dis Clin North Am. 2014;40(4):699-710.

Gelber AC. Osteoarthritis research: current state of the evidence. Curr Opin Rheumatol.2015;27(3):273-275

Glyn-Jones S, Palmer AJ, Agricola R. Osteoarthritis. Lancet. 2015; 386(9991):376-387.

Hensor EMA, Dube B, Kingsbury SR, Tennant A, Conaghan PG. Toward a Clinical Definition of Early Osteoarthritis: Onset of Patient-Reported Knee Pain Begins on Stairs. Data From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2015;67(1):40-47.

Jones LD, Bottomley N, Harris K, Jackson W, Price AJ, Beard DJ. The clinical symptom profile of early radiographic knee arthritis: a pain and function comparison with advanced disease. Knee Surg Sports Traumatol Arthrosc.2016;24(1):161-168

Luyten FP, Denti M, Filardo G, Kon E, Engebretsen L. Definition and classification of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2012;20(3):401-406.

Luyten FP, Denti M, Filardo G, Kon E, Engebretsen L. Definition and classification of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2015;20(3):401-406.

Madry H, Kon E, Condello V. Early osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy. 2016;24(6):1753-1762.

Thorstensson CA, Andersson ML, Jonsson H, Saxne T, Petersson IF. Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria. Ann Rheum Dis. 2009;68(12):1890-1893.

Алексеева Л.И., Таскина Е.А., Кашеварова СОВPEМЕННАЯ РЕВМАТОЛОГИЯ №2’19 ЛЕКЦИЯ 9, 2019;13(2):9–Н.Г.ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия.

Гнилорыбов А.М., Хрещакова Т.П. Роль олигомерного матриксного протеина хряща в диагностике поражения суставов. http://rheumatology.org.ua/blog/articles/392/ (дата обращения 08.08.2014).

Современный подход к патогенезу, диагностике и лечению остеоартроза коленного сустава, Е.М. Лисицына, М.П. Лисицын, А.М. Заремук, Журнал: Эндоскопическая хирургия, 6, 2016г.

Эффективность экстракта мартинии душистой (сустамар) при остеоартритах, поясничной боли и фибромиалгии: обзор исследований Авторы: Савустьяненко А.В. - Донецкий национальный медицинский университет им. М. Горького , 2018г

Matkarimova, A. I., & Toshtemirov, E. N. (2017). Assessment in teaching a foreign language. Molodoi uchenii, (5), 432-434.

Маткаримова, А. И., & Тоштемиров, Э. Н. (2017). Assessment in teaching a foreign language. Молодой ученый, (5), 432-434.

Matkarimova, A. I. (2015). Linguocultural Features of the Semantic Field of" Respect" in Different Systems of Languages. Advanced Studies in science Theory and practice. London.

Matkarimova, A. I. (2020). Linguokulturological features of semantic fields of «respect» in modern world. Философия и культура в гуманитарном дискурсе, 200-202.

Matkarimova, A. I. (2020). Linguokulturological features of semantic fields of «respect» in modern world. In Философия и культура в гуманитарном дискурсе (pp. 200-202).

Маткаримова, А. И. (2016). Some reflections on the semantic field of" respect" in different system of languages. In Актуальные проблемы филологии (pp. 105-107).

Маткаримова, А. И., & Тоштемиров, Э. Н. (2023). Дейктические единицы в языкознании. In Философия и культура в гуманитарном дискурсе (pp. 104-107).

Shakirova, M. O., Matkarimova, A. I., & Toshtemirov, E. N. (2022). Problems of translating of English complex sentences connected with «lest» into Uzbek. In Философия и культура в гуманитарном дискурсе (pp. 249-251).

Solijonov, I., & Matkarimova, A. I. (2022). Problems of translation of the English the “nominative sentences” into Uzbek. In Философия и культура в гуманитарном дискурсе (pp. 230-232).

Azamjonova, K. N., & Matkarimova, A. I. (2021). Special psychological aspects of learning foreign languages. In Философия и культура в гуманитарном дискурсе (pp. 282-284).

Matkarimova, A. I., & Toshtemirov, E. N. (2021). Problems of homogeneous direct objects in different systems of language. In Философия и культура в гуманитарном дискурсе (pp. 247-252).

Matkarimova, A. (2020, December). LINGUVOGONITIC FUNDAMENTALS OF THE CONCEPT" RESPECT". In Конференции.

Ismoilovna, M. A. (2019). SOME REFLECTIONS ON EXPRESSING THE SEMANTICS OF “RESPECT”. European Journal of Research and Reflection in Educational Sciences Vol, 7(12).

Matkarimova, A., Toshtemirov, E., & Hamidov, B. (2019). VERBALIZATION OF THE CONCEPT OF FAITH/BELIEF BY MEANS OF LEXEMES AND PHRASEOLOGICAL UNITS IN MODERN ENGLISH AND UZBEK. Интернаука, (45-2), 69-71.

Маткаримова, А. И., & Позилова, Н. М. (2019). TURLI TIZIMLI TILLARDA IKKINCHI SHAXS OLMOSHLARINING PRAGMATIK XUSUSIYATLARI HAQIDA AYRIM MULOHAZALAR. In ИННОВАЦИОННЫЕ ПОДХОДЫ В СОВРЕМЕННОЙ НАУКЕ (pp. 96-100).

Маткаримова, А. И., Тоштемиров, Э. Н., & Хамидов, Б. А. (2015). Интерактивные методы обучения иностранному языку. In Современная филология (pp. 61-62).

Рахимов, С. Р., & Маткаримова, А. И. (2012). CЕМАНТИЧЕСКОЕ ПОЛЕ" УВАЖЕНИЯ" В АНГЛИЙСКОМ И УЗБЕКСКОМ ЯЗЫКАХ. Педагогические науки, (4), 51-53.

Маткаримова, А. И. (2012). Способы возвеличивания личности человека языковыми средствами (на материале английского и русского языка). Вопросы филологических наук, (6), 39-41.

Sayidirahimova, N. S., & Kabulova, U. S. (2020). General Theoretical Aspects In Synchronical Typological Learning Of English Adverbs (Adverb Goals). Published in International Journal of Research Available at https://edupediapublications. org/journals. Available online: http://edupediapublications. org/journals/index. php/IJR/Р.-Indiya, 384-398.

Kabulova, U. (2023). " FILOLOGIYA" TERMINI HAQIDA. Scienceweb academic papers collection.

Sayidmaxamadovna, K. U., & Isakovna, B. R. (2023). “PAREMIYA” HAQIDA. Finland International Scientific Journal of Education, Social Science & Humanities, 11(2), 773-777.

Sayidmaxamadovna, K. U., & Muratovna, K. Z. (2023). “FRAZEОLОGIZM” ATAMASI HAQIDA. Finland International Scientific Journal of Education, Social Science & Humanities, 11(2), 711-715.

Muratovna, K. Z., & Sayidmaxamadovna, K. U. (2023). TILSHUNOSLARNING “FRAZEOLOGIK BIRLIK” ATAMASI HAQIDAGI QARASHLARI. Finland International Scientific Journal of Education, Social Science & Humanities, 11(2), 768-772.

Sayidmahamadovna, S. N., Saiidmakhadovna, K. U., Komiljonovna, K. G., Azimjanovna, T. O., & Ganiyevna, M. D. (2020). AMBIGUITIES IN UZBEK LANGUAGE-SYNTACTIC HOMONYMS. PalArch's Journal of Archaeology of Egypt/Egyptology, 17(7), 6542-6548.

Madina, K., & Nilufar, V. (2022). Etymological Analysis of Binary Opposition of “Bakht and Bakhtsizlik”(Happiness and Unhappiness). Eurasian Journal of Learning and Academic Teaching, 8, 131-134.

Madina Kosimova. (2021). THE EXPRESSION OF CONCEPTUAL UNITS OF HAPPINESS IN TERMS OF PARTS OF SPEECH. International Scientific and Current Research Conferences, 1(1), 112–116.

Sayidmaxamadovna, K. U., & Isakovna, B. R. (2023). “PAREMIYA” HAQIDA. Finland International Scientific Journal of Education, Social Science & Humanities, 11(2), 773-777.

Muratovna, K. Z., & Sayidmaxamadovna, K. U. (2023). TILSHUNOSLARNING “FRAZEOLOGIK BIRLIK” ATAMASI HAQIDAGI QARASHLARI. Finland International Scientific Journal of Education, Social Science & Humanities, 11(2), 768-772.

Sayidmaxamadovna, K. U., & Muratovna, K. Z. (2023). “FRAZEОLОGIZM” ATAMASI HAQIDA. Finland International Scientific Journal of Education, Social Science & Humanities, 11(2), 711-715.

Muratovna, K. Z., & Akramjonovna, A. M. (2023). FONOSEMANTIKA VA FONOSTILISTIKANI O ‘QITISHDAGI MUAMMOLAR. Finland International Scientific Journal of Education, Social Science & Humanities, 11(1), 508-511.

Каримов, К. Н. (2023). РУС ТИЛИ ФАЛСАФИЙ ТЕРМИНЛАРИНИНГ ТУЗИЛИШИГА КЎРА ТАВСИФИ. THEORY AND ANALYTICAL ASPECTS OF RECENT RESEARCH, 1(12), 94-99.

Каримов, К. Н. (2022). ИНГЛИЗ ТИЛИ ФАЛСАФИЙ ТЕРМИНЛАРИНИНГ ТУЗИЛИШИГА КЎРА ТАВСИФИ. JOURNAL OF INNOVATIONS IN SCIENTIFIC AND EDUCATIONAL RESEARCH, 5(4), 432-437.

Каримов, К. Н. (2022). ТЕРМИНОЛОГИЯНИНГ ИНГЛИЗ ТИЛШУНОСЛИГИДАГИ ТАДҚИҚИ. INNOVATION IN THE MODERN EDUCATION SYSTEM, 3(25), 208-213.

Каримов, К. Н. (2022). СОҲАГА ОИД ТЕРМИНЛАРНИНГ ЎЗБЕК ТИЛШУНОСЛИГИДАГИ ТАДҚИҚИ. O'ZBEKISTONDA FANLARARO INNOVATSIYALAR VA ILMIY TADQIQOTLAR JURNALI, 2(14), 1070-1080.

Nasriddinovich, K. K. (2022). Description of Philosophical Terms of the Uzbek Language According to Their Structure. Finland International Scientific Journal of Education, Social Science & Humanities, 10(12), 462-467.

Nasriddinovich, K. K. (2022). Description of Philosophical Terms of the Uzbek Language According to Their Structure.

Karimov, K. N. (2020). MENTALITY IN ENGLISH AND UZBEK PROVERBS. In European research: innovation in science, education and techology (pp. 74-75).

Jasur, E., & Zulayho, A. (2023). STYLISTICS PROBLEMS IN TRANSLATION. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 23(3), 73-75.

Jasurbek, E., Gulxumor, X., & Roziya, B. (2023). TRANSLATION THEORY AND PRACTICE. Journal of new century innovations, 30(2), 156-158.

Jasur, E., & Oydin, K. (2023). GRAMMATICAL PROBLEMS IN TRANSLATION.

Jasur, E., & Avazbek’s, Y. M. (2023). LEXICAL AND SEMANTIC PROBLEMS IN TRANSLATION. Новости образования: исследование в XXI веке, 1(11), 168-171.

Jasurbek, E., & Zebiniso, S. (2023). BOLALAR ADABIYOTIDA ONOMATOPEYANING ISHLATILISHI. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 22(1), 119-121.

Qadambayevich, E. J., & Sulaymonovich, Q. M. (2023). GLOBAL IQTISODIYOT MUAMMOLARI VA MILLIY IQTISODIYOTNI YANADA RIVOJLANTIRISH. Conferencea, 281-288.

Egamberdiyev, J. (2023). MAIN UNITS OF VERBAL COMMUNICATION. «ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ».

Jasurbek, E., Irodaxon, E., & Malohatoy, Y. (2023). CROSS–CULTURAL AWARENESS. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 20(4), 114-118.

Egamberdiyev, J., Egamberdiyeva, I., & Baratbayeva, N. (2023). EXTRALINGUISTIC ISSUES IN CROSS-CULTURAL COMMUNICATION: BODY LANGUAGE, TABOOS. Наука и инновация, 1(3), 49-52.

Iroda, E., Arofat, U., & Jasur, E. (2023). LANGUAGE AND CULTURE IN ENGLISH CLASSROOMS: GREETINGS, WAYS OF EXPRESSING POLITENESS.

Egamberdiyev, J. J. (2021). Phytomorphic Metaphors and Their Types. Academicia Globe, 2(05), 248-250.

Jahongirovich, E. J. (2018). THE ROLE OF NATIONAL AND SOCIAL REPRESENTATIONS IN FIGURATIVE INTERPRETATION OF A WORD MEANING. ANGLISTICUM. Journal of the Association-Institute for English Language and American Studies, 7(10), 82-88.