MORPHOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF DRUG-RESISTANT PULMONARY TUBERCULOSIS IN UZBEKISTAN
Abstract
The study examines the morphological and epidemiological features of drug-resistant tuberculosis (DR-TB), with a focus on multidrug-resistant tuberculosis (MDR-TB) in Uzbekistan. The aim is to identify key patterns of disease progression and the challenges in treatment caused by bacterial resistance. Methods included a comprehensive analysis of epidemiological data and morphological observations of lung tissue affected by DR-TB. Results show a high prevalence of primary and secondary resistance in regions with dense populations and active migration, such as Tashkent and the Fergana Valley. Morphological findings revealed extensive lung tissue damage, including giant caverns, caseous necrosis, and lymph node involvement. The research highlights the role of immune suppression in the rapid progression of DR-TB and the necessity for timely and accurate diagnosis. The novelty lies in the regional focus on Uzbekistan and the proposed integration of immunomodulatory therapies with existing chemotherapy protocols to improve patient outcomes. These findings emphasize the importance of adapting global strategies to local epidemiological and healthcare contexts.
References
Belilovsky, E. M., Kalinovskaya, A. A. Tuberculosis: New Approaches to Diagnosis and Treatment. Medical Gazette, 2020.
Gladyshev, V. A., Ivanov, S. I. Drug Resistance of Mycobacterium Tuberculosis. Russian Journal of Infectious Pathology, 2019; 18(3): 45-52.
Malyshev, N. A., Kiselev, V. I. Modern Problems of Tuberculosis Therapy. Pulmonology, 2018; 4: 37-45.
Sorokina, E. V., Karpova, L. V. Multidrug-Resistant Tuberculosis: Epidemiology and Treatment. Russian Medical Journal, 2017; 25(5): 123-130.
Fedotova, O. A., Smirnov, P. I. Immunological Aspects of Drug-Resistant Tuberculosis. Bulletin of Phthisiopulmonology, 2021; 29(2): 89-96.
Petrov, A. V., Vasiliev, I. A. Morphological Changes in Pulmonary Tuberculosis. Pathological Anatomy, 2018; 22(1): 74-81.
Nikiforov, V. V., Sidorov, D. A. Problems in the Treatment of Multidrug-Resistant Tuberculosis. Medical Almanac, 2019; 15(6): 55-63.
Vasilyeva, M. N., Zhukova, T. I. Effectiveness of New Chemotherapy Regimens for Tuberculosis. Russian Journal of Clinical Oncology, 2020; 14(4): 213-220.
Ilyin, Y. S., Kuznetsov, A. P. Pathogenesis and Morphology of the Tuberculosis Process. Medical Bulletin, 2017; 21(3): 98-104.
Savinova, O. S., Dmitriev, A. L. Epidemiological Features of Tuberculosis in Russia. Health of the Nation, 2021; 33(2): 45-51.
