https://sirpublishers.org/index.php/jomap/issue/feedJOURNAL OF MEDICINE AND PHARMACY2025-03-20T00:00:00-06:00Open Journal Systems<p><strong>ISSN(Online):</strong> 2984-7117<br /><strong>Publisher:</strong> SIR Publishers<br /><strong>Frequency:</strong> Once a month<br /><strong>Chief Editor:</strong> Dr. Nasser Thallaj<br /><strong>Language:</strong> English<br /><strong>Country of Origin:</strong> Philippines<br /><a href="http://sjifactor.com/passport.php?id=23193"><strong>SJIF Impact Factor (2024): 6.879</strong></a></p>https://sirpublishers.org/index.php/jomap/article/view/1045MODULATION OF HYPERTHERMIC EFFECT OF PYROGENS BY CALCIUM CHANNEL BLOCKATAROMES2025-03-19T18:08:00-06:00Z.Z. Khakimovsardorsultonov20010704@gmail.comA.Kh. Rakhmanovsardorsultonov20010704@gmail.comN.B. Bekovafarspublishers@gmail.com<p>The effect of calcium channel blockers on the course of fever was studied in animals with various models of pyrexia. It was found that calcium channel blockers significantly modify the hyperthermic effect of pyrogens, which is manifested in a decrease in body temperature. Diltiazem and cinnarizine slightly more than amlodipine, on the model of fever induced by pyrogenal - lipopolysaccharide produced by microorganisms Pseudomonas aeruginosa exhibits a distinct hypothermic effect, not inferior in activity to diclofenac sodium. On the model of hyperthermia caused by baker's yeast, calcium channel blockers exhibit a more pronounced hypothermic effect. The mechanism of antipyretic action of representatives of calcium channel blockers is probably associated not only with the development of vasodilation, but also with a change in the level of proinflammatory cytokines.</p>2025-03-19T00:00:00-06:00Copyright (c) 2025